Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Identifieur interne : 000061 ( France/Analysis ); précédent : 000060; suivant : 000062Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Auteurs : Brice Laurens [France] ; Radu Constantinescu [Suède] ; Roy Freeman [États-Unis] ; Alexander Gerhard [Royaume-Uni] ; Kurt Jellinger [Autriche] ; Andreas Jeromin [États-Unis] ; Florian Krismer [Autriche] ; Brit Mollenhauer [Allemagne] ; Michael G. Schlossmacher [Canada] ; Leslie M. Shaw ; Marcel M. Verbeek [Pays-Bas] ; Gregor K. Wenning [Autriche] ; Kristian Winge [Danemark] ; Jing Zhang [États-Unis] ; Wassilios G. Meissner [France]Source :
- Neurobiology of disease [ 1095-953X ] ; 2015.
English descriptors
- KwdEn :
- Animals, Biomarkers (blood), Biomarkers (cerebrospinal fluid), Brain (metabolism), Catecholamines (analysis), Humans, Intermediate Filaments (metabolism), Multiple System Atrophy (blood), Multiple System Atrophy (cerebrospinal fluid), Multiple System Atrophy (diagnosis), Nerve Degeneration (metabolism), alpha-Synuclein (analysis).
- MESH :
- chemical , analysis : Catecholamines, alpha-Synuclein.
- chemical , blood : Biomarkers.
- chemical , cerebrospinal fluid : Biomarkers.
- blood : Multiple System Atrophy.
- cerebrospinal fluid : Multiple System Atrophy.
- diagnosis : Multiple System Atrophy.
- metabolism : Brain, Intermediate Filaments, Nerve Degeneration.
- Animals, Humans.
Abstract
Despite growing research efforts, no reliable biomarker currently exists for the diagnosis and prognosis of multiple system atrophy (MSA). Such biomarkers are urgently needed to improve diagnostic accuracy, prognostic guidance and also to serve as efficacy measures or surrogates of target engagement for future clinical trials. We here review candidate fluid biomarkers for MSA and provide considerations for further developments and harmonization of standard operating procedures. A PubMed search was performed until April 24, 2015 to review the literature with regard to candidate blood and cerebrospinal fluid (CSF) biomarkers for MSA. Abstracts of 1760 studies were retrieved and screened for eligibility. The final list included 60 studies assessing fluid biomarkers in patients with MSA. Most studies have focused on alpha-synuclein, markers of axonal degeneration or catecholamines. Their results suggest that combining several CSF fluid biomarkers may be more successful than using single markers, at least for the diagnosis. Currently, the clinically most useful markers may comprise a combination of the light chain of neurofilament (which is consistently elevated in MSA compared to controls and Parkinson's disease), metabolites of the catecholamine pathway and proteins such as α-synuclein, DJ-1 and total-tau. Beyond future efforts in biomarker discovery, the harmonization of standard operating procedures will be crucial for future success.
DOI: 10.1016/j.nbd.2015.05.004
PubMed: 25982836
Affiliations:
- Allemagne, Autriche, Canada, Danemark, France, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Aquitaine, Grand Manchester, Gueldre, Hovedstaden, Massachusetts, Nouvelle-Aquitaine, Tyrol (Land)
- Bordeaux, Boston, Copenhague, Innsbruck, Manchester, Nimègue
- Université de Manchester, Université de médecine d'Innsbruck
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000457
- to stream PubMed, to step Curation: 000457
- to stream PubMed, to step Checkpoint: 000457
- to stream Ncbi, to step Merge: 001B67
- to stream Ncbi, to step Curation: 001B67
- to stream Ncbi, to step Checkpoint: 001B67
- to stream Main, to step Merge: 000727
- to stream Main, to step Curation: 000726
- to stream Main, to step Exploration: 000726
- to stream France, to step Extraction: 000061
Links to Exploration step
pubmed:25982836Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.</title><author><name sortKey="Laurens, Brice" sort="Laurens, Brice" uniqKey="Laurens B" first="Brice" last="Laurens">Brice Laurens</name><affiliation wicri:level="1"><nlm:affiliation>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux</wicri:regionArea><wicri:noRegion>33076 Bordeaux</wicri:noRegion><wicri:noRegion>33076 Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Sahlgrenska University Hospital, 413 45 Göteborg</wicri:regionArea><wicri:noRegion>413 45 Göteborg</wicri:noRegion></affiliation></author><author><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Brain Behaviour and Mental Heath, University of Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain Behaviour and Mental Heath, University of Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna</wicri:regionArea><wicri:noRegion>A-1070 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><affiliation wicri:level="2"><nlm:affiliation>Quanterix, Inc., Lexington, MA 021421, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quanterix, Inc., Lexington, MA 021421</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Krismer, Florian" sort="Krismer, Florian" uniqKey="Krismer F" first="Florian" last="Krismer">Florian Krismer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena-Klinik, Kassel, Germany and Department of Neuropathology, University Medical Center Goettingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Kassel, Germany and Department of Neuropathology, University Medical Center Goettingen</wicri:regionArea><wicri:noRegion>University Medical Center Goettingen</wicri:noRegion><wicri:noRegion>University Medical Center Goettingen</wicri:noRegion><wicri:noRegion>University Medical Center Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G" last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><nlm:affiliation>Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Leslie M" sort="Shaw, Leslie M" uniqKey="Shaw L" first="Leslie M" last="Shaw">Leslie M. Shaw</name><affiliation><nlm:affiliation>Perelman School of Medicine, University of Pennsylvania.</nlm:affiliation><wicri:noCountry code="subField">University of Pennsylvania</wicri:noCountry></affiliation></author><author><name sortKey="Verbeek, Marcel M" sort="Verbeek, Marcel M" uniqKey="Verbeek M" first="Marcel M" last="Verbeek">Marcel M. Verbeek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Laboratory Medicine, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Laboratory Medicine, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Winge, Kristian" sort="Winge, Kristian" uniqKey="Winge K" first="Kristian" last="Winge">Kristian Winge</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Bispebjerg University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Neurology, Bispebjerg University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of WA, Seattle, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of WA, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><affiliation wicri:level="1"><nlm:affiliation>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France. Electronic address: wassilios.meissner@chu-bordeaux.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux</wicri:regionArea><wicri:noRegion>33076 Bordeaux</wicri:noRegion><wicri:noRegion>33076 Bordeaux</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25982836</idno><idno type="pmid">25982836</idno><idno type="doi">10.1016/j.nbd.2015.05.004</idno><idno type="wicri:Area/PubMed/Corpus">000457</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000457</idno><idno type="wicri:Area/PubMed/Curation">000457</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000457</idno><idno type="wicri:Area/PubMed/Checkpoint">000457</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000457</idno><idno type="wicri:Area/Ncbi/Merge">001B67</idno><idno type="wicri:Area/Ncbi/Curation">001B67</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B67</idno><idno type="wicri:Area/Main/Merge">000727</idno><idno type="wicri:Area/Main/Curation">000726</idno><idno type="wicri:Area/Main/Exploration">000726</idno><idno type="wicri:Area/France/Extraction">000061</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.</title><author><name sortKey="Laurens, Brice" sort="Laurens, Brice" uniqKey="Laurens B" first="Brice" last="Laurens">Brice Laurens</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Sahlgrenska University Hospital, 413 45 Göteborg</wicri:regionArea><wicri:noRegion>413 45 Göteborg</wicri:noRegion></affiliation></author><author><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Brain Behaviour and Mental Heath, University of Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain Behaviour and Mental Heath, University of Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna</wicri:regionArea><wicri:noRegion>A-1070 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><affiliation wicri:level="2"><nlm:affiliation>Quanterix, Inc., Lexington, MA 021421, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quanterix, Inc., Lexington, MA 021421</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Krismer, Florian" sort="Krismer, Florian" uniqKey="Krismer F" first="Florian" last="Krismer">Florian Krismer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena-Klinik, Kassel, Germany and Department of Neuropathology, University Medical Center Goettingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Kassel, Germany and Department of Neuropathology, University Medical Center Goettingen</wicri:regionArea><wicri:noRegion>University Medical Center Goettingen</wicri:noRegion><wicri:noRegion>University Medical Center Goettingen</wicri:noRegion><wicri:noRegion>University Medical Center Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G" last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><nlm:affiliation>Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Leslie M" sort="Shaw, Leslie M" uniqKey="Shaw L" first="Leslie M" last="Shaw">Leslie M. Shaw</name><affiliation><nlm:affiliation>Perelman School of Medicine, University of Pennsylvania.</nlm:affiliation><wicri:noCountry code="subField">University of Pennsylvania</wicri:noCountry></affiliation></author><author><name sortKey="Verbeek, Marcel M" sort="Verbeek, Marcel M" uniqKey="Verbeek M" first="Marcel M" last="Verbeek">Marcel M. Verbeek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Laboratory Medicine, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Laboratory Medicine, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Winge, Kristian" sort="Winge, Kristian" uniqKey="Winge K" first="Kristian" last="Winge">Kristian Winge</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Bispebjerg University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Neurology, Bispebjerg University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of WA, Seattle, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of WA, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><affiliation wicri:level="1"><nlm:affiliation>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France. Electronic address: wassilios.meissner@chu-bordeaux.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux</wicri:regionArea><wicri:noRegion>33076 Bordeaux</wicri:noRegion><wicri:noRegion>33076 Bordeaux</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="eISSN">1095-953X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomarkers (blood)</term><term>Biomarkers (cerebrospinal fluid)</term><term>Brain (metabolism)</term><term>Catecholamines (analysis)</term><term>Humans</term><term>Intermediate Filaments (metabolism)</term><term>Multiple System Atrophy (blood)</term><term>Multiple System Atrophy (cerebrospinal fluid)</term><term>Multiple System Atrophy (diagnosis)</term><term>Nerve Degeneration (metabolism)</term><term>alpha-Synuclein (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Catecholamines</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Intermediate Filaments</term><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite growing research efforts, no reliable biomarker currently exists for the diagnosis and prognosis of multiple system atrophy (MSA). Such biomarkers are urgently needed to improve diagnostic accuracy, prognostic guidance and also to serve as efficacy measures or surrogates of target engagement for future clinical trials. We here review candidate fluid biomarkers for MSA and provide considerations for further developments and harmonization of standard operating procedures. A PubMed search was performed until April 24, 2015 to review the literature with regard to candidate blood and cerebrospinal fluid (CSF) biomarkers for MSA. Abstracts of 1760 studies were retrieved and screened for eligibility. The final list included 60 studies assessing fluid biomarkers in patients with MSA. Most studies have focused on alpha-synuclein, markers of axonal degeneration or catecholamines. Their results suggest that combining several CSF fluid biomarkers may be more successful than using single markers, at least for the diagnosis. Currently, the clinically most useful markers may comprise a combination of the light chain of neurofilament (which is consistently elevated in MSA compared to controls and Parkinson's disease), metabolites of the catecholamine pathway and proteins such as α-synuclein, DJ-1 and total-tau. Beyond future efforts in biomarker discovery, the harmonization of standard operating procedures will be crucial for future success.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Canada</li><li>Danemark</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Grand Manchester</li><li>Gueldre</li><li>Hovedstaden</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Tyrol (Land)</li></region><settlement><li>Bordeaux</li><li>Boston</li><li>Copenhague</li><li>Innsbruck</li><li>Manchester</li><li>Nimègue</li></settlement><orgName><li>Université de Manchester</li><li>Université de médecine d'Innsbruck</li></orgName></list><tree><noCountry><name sortKey="Shaw, Leslie M" sort="Shaw, Leslie M" uniqKey="Shaw L" first="Leslie M" last="Shaw">Leslie M. Shaw</name></noCountry><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Laurens, Brice" sort="Laurens, Brice" uniqKey="Laurens B" first="Brice" last="Laurens">Brice Laurens</name></region><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name></country><country name="Suède"><noRegion><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name></region><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name></region></country><country name="Autriche"><noRegion><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name></noRegion><name sortKey="Krismer, Florian" sort="Krismer, Florian" uniqKey="Krismer F" first="Florian" last="Krismer">Florian Krismer</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name></country><country name="Allemagne"><noRegion><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G" last="Schlossmacher">Michael G. Schlossmacher</name></noRegion></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Verbeek, Marcel M" sort="Verbeek, Marcel M" uniqKey="Verbeek M" first="Marcel M" last="Verbeek">Marcel M. Verbeek</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Winge, Kristian" sort="Winge, Kristian" uniqKey="Winge K" first="Kristian" last="Winge">Kristian Winge</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000061 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000061 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= pubmed:25982836
|texte= Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:25982836" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |